URC-Hypoxia is a research project funded by the Marie Skłodowska-Curie Actions that aims to uncover how living systems cope with the absence of oxygen. While human tissues are highly vulnerable to hypoxia, many organisms have evolved remarkable resilience, tolerating prolonged periods of low oxygen. This project seeks to understand the molecular basis of this resilience by focusing on early redox signaling events and time-resolved stress responses. Using the insect model Tenebrio molitor, URC-Hypoxia integrates redox biology, transcriptomics, and proteomics to map how cells respond to oxygen deprivation and to identify mechanisms that may inspire new strategies to mitigate hypoxia-related damage in human disease.