Research Projects
Here are my ongoing and finalized research projects.
Ongoing Projects
Synthesis of membrane-active peptide and N-acyl homoserine lactone conjugates for the control of bacterial biofilms via quorum sensing modulation (2023-ongoing)
My role: Collaborating Researcher
Principal Investigator: Guilherme D. Brand
Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Biochemical Adaptations to Extreme Environmental Conditions: Investigating Endogenous Antioxidants, Oxidative Stress, and Metabolic Depression in Animals (2022-ongoing)
My role: Principal Investigator
Principal Investigator: Daniel C. Moreira
Funding: University of Brasilia (UnB)
Smartphones as "Portable Chemical Analyzers" to Acquire Analytical Signals from Colorimetric Assays (2022-ongoing)
My role: Principal Investigator
Principal Investigator: Daniel C. Moreira
Funding: University of Brasilia (UnB)
Products:
Moreira, D.C. 2022. RGBradford: Accurate measurement of protein concentration using a smartphone camera and the blue to green intensity ratio. Analytical Biochemistry, 655, 114839. DOI.
Moreira, D.C. 2023. RGBradford: Protein quantitation with a smartphone camera. Journal of Visualized Experiments, 199, e65547. DOI.
Featured in:
PEP-GLIA: Characterization of the mechanism of an antioxidant peptide from the Brazilian biodiversity with neuroprotective effect (2022-2024)
My role: Responsible Investigator and Post-Doc Junior Researcher in the Glial Cell Biology Group, Institute for Research & Innovation in Health (i3S), University of Porto, Portugal.
Responsible Investigator: Daniel C. Moreira
Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Product:
Moreira, D.C., Batagin-Neto, A and Leite, J.R.S.A. 2024. Frog-derived neuroprotective peptides. In M.R. de Oliveira (Ed.), Natural Molecules in Neuroprotection and Neurotoxicity. Elsevier. Link. DOI.
Finalized Projects
VIDA-FROG: Valorization of Molecules Isolated from Portuguese Amphibians (2018-2023)
My role: Collaborating Researcher
Principal Investigators: Peter Eaton and Massuo Kato
Funding: Fundação para a Ciência e a Tecnologia (FCT - Portugal) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP - Brazil).
Products:
Plácido, A., Bueno, J., Barbosa, E.A., Moreira, D.C., Dias, J.N., Cabral, W.F., Albuquerque, P., Bessa, L.J., Freitas, J. et al. 2020. The antioxidant peptide salamandrin-I: first bioactive peptide identified from skin secretion of salamandra genus (Salamandra salamandra). Biomolecules, 10(4), 512. DOI.
Barbosa, E.A., Plácido A., Moreira, D.C., Albuquerque, L., Dematei, A., Silva-Carvalho, A.E., Cabral, W.F., Báo, S.N., Saldanha-Araújo, F. et al. 2021. The peptide secreted at the water to land transition in a model amphibian has antioxidant effects. Proceedings of the Royal Society B: Biological Sciences, 288, 20211531. DOI.
Barros, A.L.A.N., Hamed, A., Marani, M., Moreira, D.C., Eaton, P., Plácido, A., Kato, M.J. and Leite, J.R.S.A. 2022. The arsenal of bioactive molecules in the skin secretion of urodele amphibians. Frontiers in Pharmacology, 12, 810821. DOI.
Plácido, A., Amaral, C.P., Teixeira, C., Nogueira, A., Brango-Venegas, J., Barbosa, E.A., Moreira, D.C., Silva-Carvalho, A.E., Silva, M.A. et al. 2022. Neuroprotective effects on microglia and insights into the structure–activity relationship of an antioxidant peptide isolated from Pelophylax perezi. Journal of Cellular and Molecular Medicine, 26, 2793–2807. DOI.
Silva-Carvalho, A.E., Natiely, N., Machado, J.V., Moreira, D.C., Brand, G.D., Leite, J.R.S.A., Placido, A, Eaton, P. and Saldanha-Araujo, F. 2023. The antioxidant peptide Salamandrin-I modulates components involved in pyroptosis and induces cell death in human leukemia cell line HL-60. Pharmaceutics, 15, 1864. DOI.
Antioxidant Systems and Oxidative Stress Markers during Metamorphosis of Holometabolous Insects (2019-2022)
My role: Principal Investigator
Principal Investigator: Daniel C. Moreira
Funding: Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF - Brazil) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Products:
Moreira, D.C., Paula, D.P. and Hermes-Lima, M. 2021. Changes in metabolism and antioxidant systems during tropical diapause in the sunflower caterpillar Chlosyne lacinia (Lepidoptera: Nymphalidae). Insect Biochemistry and Molecular Biology, 134, 103581. DOI.
Moreira, D.C. and Hermes-Lima, M. 2022. Redox imbalance and oxidative eustress during larval-pupal transition in a holometabolous insect. Free Radical Biology and Medicine, 192 (S1), 130. DOI.
Submitted.
Preparation for Oxidative Stress: Ecophysiology and Evolution (2018-2022)
My role: Collaborating Researcher
Principal Investigator: Marcelo Hermes-Lima
Funding: Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF - Brazil) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Products:
Oliveira, M.F., Geihs, M.A., Moreira, D.C. and Hermes-Lima, M. 2018. Is “Preparation for Oxidative Stress” a case of physiological conditioning hormesis? Frontiers in Physiology, 9, 945. DOI.
Giraud-Billoud, M., Rivera-Ingraham, G.A., Moreira, D.C., Burmester, T., Castro-Vaquez, A., Carvajalino-Fernández, J.M., Dafre, A., Niu, C., Tremblay, N. et al. 2019. Twenty years of the 'Preparation for Oxidative Stress' (POS) theory: Ecophysiological advantages and molecular strategies. Comparative Biochemistry and Physiology A, 234, 36–49. DOI.
Geihs, M.A., Moreira, D.C., López-Martínez, G., Minari, M., Ferreira-Cravo, M., Carvajalino-Fernández, J.M. and Hermes-Lima, M. 2020. Ultraviolet radiation triggers “preparation for oxidative stress” antioxidant response in animals: Similarities and interplay with other stressors. Comparative Biochemistry and Physiology A, 239, 110585. DOI.
Moreira, D.C., Carvajalino-Fernández, J.M., Silva, W.P., Kuzniewski, F., Navas, C.A., Carvalho, J.E. and Hermes-Lima, M. 2020. Preparation for oxidative stress in Proceratophrys cristiceps (Anura, Odontophrynidae) naturally estivating in the Brazilian Caatinga. Science of the Total Environment, 723, 137957. DOI.
Moreira, D.C., Sabino, M.A.C.T., Kuzniewski, F.T.B., Furtado-Filho, O.V., Carvajalino-Fernández, J.M., Angelini, R., Freire, C.A. and Hermes-Lima, M. 2021. Redox metabolism in mussels (Brachidontes solisianus) under the influence of tides in a rocky beach in Southern Brazil. Estuarine, Coastal and Shelf Science, 258, 107424. DOI.
Moreira, D.C., Carvajalino-Fernández, J.M., Navas, C.A., de Carvalho, J.E. and Hermes-Lima, M. 2021. Metabolic and redox biomarkers in skeletal muscle underlie physiological adaptations of two estivating anuran species in a South American semi-arid environment. Frontiers in Physiology, 12, 769833 . DOI.
Moreira, D.C., Campos, E.G., Giraud-Billoud, M., Storey, K.B. and Hermes-Lima, M. 2023. Commentary: On the merit of an early contributor of the “Preparation for Oxidative Stress” (POS) theory. Comparative Biochemistry and Physiology A, 276, 111341. DOI.
Ferreira-Cravo, M.*, Moreira, D.C.* and Hermes-Lima, M. 2023. Glutathione depletion disrupts redox homeostasis in an anoxia-tolerant invertebrate. Antioxidants, 12, 1197. DOI. *These authors contributed equally.
Moreira, D.C., Sabino, M.A.C.T., Minari, M., Kuzniewski, F.T.B., Angelini, R., Hermes-Lima, M. 2023. The role of solar radiation and tidal emersion on oxidative stress and glutathione synthesis in mussels exposed to air. PeerJ, 11, e15345. DOI. Citations.
Giraud-Biloud, M., Moreira, D.C., Minari, M., Andreyeva, A., Campos, E.G., Carvajalino-Fernández, J.M., Istomina, A., Michaelidis, B., Niu, C. et al. 2024. Evidence Supporting the 'Preparation for Oxidative Stress' (POS) Strategy in Animals in Their Natural Environment. Comparative Biochemistry and Physiology A, 293, 111626. DOI.
Nutri Tech: Development of Natural Products Aimed at Improving the Quality of Life (2021-2022)
My role: Technical Coordinator
Project Manager: José Roberto S. A. Leite
Funding: Federal parliamentary amendment.
Product:
Video (in Portuguese) – https://youtu.be/pliDslGz6VQ
Verification of Antiviral Activity of Intragenic Antimicrobial Peptides (IAPs) (2020-2021)
My role: Collaborating Researcher
Principal Investigator: Guilherme D. Brand
Funding: Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF - Brazil).
Video (in Portuguese): https://youtu.be/vDkgAH_p1EM
Development of a Bioprospecting Platform for Screening Biodiversity for Antioxidant Peptides with Neuroprotective Potential (2018-2020)
My role: Collaborating Researcher
Principal Investigator: José Roberto S. A. Leite
Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Product:
Barbosa, E., Oliveira, A., Plácido, A., Socodato, R., Portugal, C.C., Mafud, A.C., Ombredane, A.S., Moreira, D.C., Vale, N. et al. 2018. Structure and function of a novel antioxidant peptide from the skin of Tropical frogs. Free Radical Biology and Medicine, 115, 68–79. DOI.
Dematei A., Costa, S.R., Moreira, D.C., Barbosa, E., Albuquerque, L.F.F., Vasconcelos, A.G., Nascimento, T., Silva, P.C., Silva-Carvalho, A.E. et al. Antioxidant and neuroprotective effects of the first tryptophyllin found in snake venom (Bothrops moojeni). Journal of Natural Products, 85, 2695–2705. DOI.
Role of Redox Metabolism in Animal Adaptation to Environmental Stressors (2014-2018)
My role: Collaborating Researcher
Principal Investigator: Marcelo Hermes-Lima
Funding: Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF - Brazil) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Products:
Hermes-Lima, M., Moreira, D.C., Rivera-Ingraham, G.A., Giraud-Billoud, M., Genaro-Mattos, T.C. and Campos, E.G. 2015. Preparation for oxidative stress under hypoxia and metabolic depression: Revisiting the proposal two decades later. Free Radical Biology and Medicine, 89, 1122–1143. DOI.
Moreira, D.C., Venancio, L.P.R., Sabino, M.A.C.T. and Hermes-Lima, M. 2016. How widespread is preparation for oxidative stress in the animal kingdom? Comparative Biochemistry and Physiology A, 200, 64–78. DOI.
Welker, A.F., Moreira, D.C. and Hermes-Lima, M. 2016. Roles of catalase and glutathione peroxidase in the tolerance of a pulmonate gastropod to anoxia and reoxygenation. Journal of Comparative Physiology B, 186(5), 553–568. DOI.
Moreira, D.C., Oliveira, M.F., Liz-Guimarães, L., Diniz-Rojas, N., Campos, E.G. and Hermes-Lima, M. 2017. Current trends and research challenges regarding “preparation for oxidative stress.” Frontiers in Physiology, 8, 702. DOI.
Moreira, D.C., Welker, A.F., Campos, E.G., de Souza, S.C.R. and Hermes-Lima, M. 2018. Subtropical hibernation in juvenile tegu lizards (Salvator merianae): insights from intestine redox dynamics. Scientific Reports, 8, 9368. DOI.
Redox Biochemistry of Polyphenols, Transition Metals and Plant Extracts (2010-2016)
My role: Collaborating Researcher
Principal Investigator: Marcelo Hermes-Lima
Funding: Fundação de Apoio à Pesquisa do Distrito Federal (FAPDF - Brazil) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil).
Products:
Dalvi, L.T., Moreira, D.C., Alonso, A., de Avellar, I.G.J. and Hermes-Lima, M. 2018. Antioxidant activity and mechanism of commercial Rama Forte persimmon fruits (Diospyros kaki). PeerJ, 6, e5223. DOI.
Dalvi, L.T., Moreira, D.C., Andrade Jr., R., Ginani, J., Alonso, A. and Hermes-Lima, M. 2017. Ellagic acid inhibits iron-mediated free radical formation. Spectrochimica Acta A, 173, 910–917. DOI.